Immunogen
Purified recombinant fragment of EphA8 (aa70-150) expressed in E. Coli.
Specificity
EphA8 Monoclonal Antibody detects endogenous levels of EphA8 protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-A family.,PTM:Phosphorylation on Tyr-616 is critical for association with FYN.,PTM:Phosphorylation on Tyr-839 modulates tyrosine kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with FYN (By similarity). Interacts with ANKS1B.,
Protein name
Ephrin type-A receptor 8
Other name
EPHA8; EEK; HEK3; KIAA1459; Ephrin type-A receptor 8; EPH- and ELK-related kinase; EPH-like kinase 3; EK3; hEK3; Tyrosine-protein kinase receptor EEK
Human protein sequence Database
P29322
Mouse protein sequence database
O09127
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Cell projection . Early endosome membrane . Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes. .
Tissue expression
Brain,Eye,
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