Molecular weight (DA)
175kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human PLXNC1. AA range:811-860
Specificity
CD232 Polyclonal Antibody detects endogenous levels of CD232 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011],
Function
function:Receptor for vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of viral semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8.,PTM:N-glycosylated.,similarity:Belongs to the plexin family.,similarity:Contains 1 Sema domain.,tissue specificity:Detected in heart, brain, lung, spleen and placenta.,
Other name
PLXNC1; VESPR; Plexin-C1; Virus-encoded semaphorin protein receptor; CD232
Human protein sequence Database
O60486
Mouse protein sequence database
Q9QZC2
Rat protein sequence database
Cellular localization
Membrane ; Single-pass type I membrane protein .
Tissue expression
Detected in heart, brain, lung, spleen and placenta.
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