Molecular weight (DA)
40kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MOS. AA range:61-110
Specificity
Mos Polyclonal Antibody detects endogenous levels of Mos protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed specifically in testis during spermatogenesis.,
Protein name
Proto-oncogene serine/threonine-protein kinase mos
Other name
MOS; Proto-oncogene serine/threonine-protein kinase mos; Oocyte maturation factor mos; Proto-oncogene c-Mos
Fields
>>Oocyte meiosis;>>Regulation of actin cytoskeleton;>>Progesterone-mediated oocyte maturation
Human protein sequence Database
P00540
Mouse protein sequence database
P00536
Rat protein sequence database
Cellular localization
intracellular,
Tissue expression
Expressed specifically in testis during spermatogenesis.
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