Molecular weight (DA)
100kD
Immunogen
The antiserum was produced against synthesized peptide derived from human HCN2. AA range:491-540
Specificity
HCN2 Polyclonal Antibody detects endogenous levels of HCN2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010],
Function
domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.,miscellaneous:Inhibited by extracellular cesium ions.,similarity:Belongs to the potassium channel HCN family.,similarity:Contains 1 cyclic nucleotide-binding domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN1. Interacts with KCNE2.,tissue specificity:Highly expressed throughout the brain. Detected at
Protein name
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Other name
HCN2; BCNG2; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; Brain cyclic nucleotide-gated channel 2; BCNG-2
Fields
>>cAMP signaling pathway;>>GnRH secretion
Human protein sequence Database
Q9UL51
Mouse protein sequence database
O88703
Rat protein sequence database
Q9JKA9
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Highly expressed throughout the brain. Detected at low levels in heart.
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