Molecular weight (DA)
25kD
Immunogen
Synthesized peptide derived from human Kallikrein-6 (Cleaved-Leu22)
Specificity
This antibody detects endogenous levels of Human Kallikrein-6 (Cleaved-Leu22, protein was cleaved amino acid sequence between 21-22 )
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Gene Name
KLK6 PRSS18 PRSS9
Protein name
Kallikrein-6 (Cleaved-Leu22)
Abbreviation
Kallikrein-6
Other name
Kallikrein-6 (EC 3.4.21.-;Neurosin;Protease M;SP59;Serine protease 18;Serine protease 9;Zyme)
Human protein sequence Database
Q92876
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.
Tissue expression
In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed
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