Immunogen
Synthesized peptide derived from human C42S2 AA range: 3-53
Specificity
This antibody detects endogenous levels of C42S2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1：50-200. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
domain:The CRIB domain mediates interaction with CDC42.,function:Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.,miscellaneous:CDC42SE2 is mapped in the genomic region associated with schizophrenia.,similarity:Belongs to the CDC42SE/SPEC family.,similarity:Contains 1 CRIB domain.,subcellular location:Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.,subunit:Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.,tissue specificity:Widely expressed. Expressed at higher level in T lymphocytes. Hi
Human protein sequence Database
Q9NRR3
Mouse protein sequence database
Q8BGH7
Rat protein sequence database
A1L1K4
Cellular localization
Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup. Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.
Tissue expression
Widely expressed. Expressed at higher level in T-lymphocytes. Highly expressed in CCRF-CEM T-lymphocytes, Jurkat T-lymphocytes, and Raji B-lymphocytes compared (at protein level).
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