Molecular weight (DA)
42kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GPR132. AA range:311-360
Specificity
GPR132 Polyclonal Antibody detects endogenous levels of GPR132 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
Function
caution:Was originally (PubMed:11474113) thought to be a receptor for lysophosphatidylcholine (LPC) and sphingosylphosphorylcholine (SPC), However, this work has been retracted.,function:Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication.,induction:By stress and DNA-damaging agents.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface.,tissue specificity:Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly e
Protein name
Probable G-protein coupled receptor 132
Other name
GPR132; G2A; Probable G-protein coupled receptor 132; G2 accumulation protein
Human protein sequence Database
Q9UNW8
Mouse protein sequence database
Q9Z282
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein . Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity). .
Tissue expression
Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region.
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